Molecular weight (DA)
34kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
ANX13 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
Function
domain:A pair of annexin repeats may form one binding site for calcium and phospholipid.,similarity:Belongs to the annexin family.,similarity:Contains 4 annexin repeats.,subcellular location:Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes.,tissue specificity:Gut specific.,
Protein name
Annexin A13 (Annexin XIII) (Annexin-13) (Intestine-specific annexin) (ISA)
Human protein sequence Database
P27216
Mouse protein sequence database
Q99JG3
Rat protein sequence database
Cellular localization
Apical cell membrane . Cell membrane ; Lipid-anchor . Cytoplasmic vesicle . Myristoylation anchors the protein to the membrane, but the protein displays also calcium-dependent, reversible binding to lipid membranes (PubMed:30610115). Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes (PubMed:1530946). .
Tissue expression
Detected in epithelial cells in colon and jejunum (at protein level). Detected in epithelial cells in jejunum.
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