Molecular weight (DA)
107kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 910-990
Specificity
GRIK5 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
Function
function:Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Associates with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels. Homomeric associations do not produce any channel activity.,
Protein name
Glutamate receptor, ionotropic kainate 5 (Excitatory amino acid receptor 2) (EAA2) (Glutamate receptor KA-2) (KA2)
Fields
>>Neuroactive ligand-receptor interaction;>>Glutamatergic synapse
Human protein sequence Database
Q16478
Mouse protein sequence database
Q61626
Rat protein sequence database
Q63273
Cellular localization
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Tissue expression
Erythroleukemia,Hippocampus,
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