Molecular weight (DA)
92kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 450-530
Specificity
HS74L Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is heat shock inducible and may act as a chaperone. The encoded protein can protect the heat-shocked cell against the harmful effects of aggregated proteins. This gene is highly expressed in leukemia cells and may be a good target for therapeutic intervention. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015],
Function
function:Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase.,induction:By heat shock.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 70 family.,subcellular location:May translocate to the nucleus after heat shock.,subunit:Homodimer.,
Gene Name
HSPA4L APG1 OSP94
Protein name
Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Osmotic stress protein 94)
Fields
>>Protein processing in endoplasmic reticulum
Human protein sequence Database
O95757
Mouse protein sequence database
P48722
Rat protein sequence database
P83581
Cellular localization
Cytoplasm . Nucleus . May translocate to the nucleus after heat shock. .
Tissue expression
Heart,Testis,
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