Molecular weight (DA)
20kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
IFNA2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold. [provided by RefSeq, Jun 2011],
Function
function:Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.,pharmaceutical:Available under the names Roferon-A (Roche) or Intron-A (Schering-Plough). Used as an anticancer drug for its antiproliferative activity.,polymorphism:Three forms exist; alpha-2a (shown here), alpha-2b and alpha-2c.,similarity:Belongs to the alpha/beta interferon family.,
Protein name
Interferon alpha-2 (IFN-alpha-2) (Interferon alpha-A) (LeIF A)
Fields
>>Cytokine-cytokine receptor interaction;>>PI3K-Akt signaling pathway;>>Necroptosis;>>Toll-like receptor signaling pathway;>>NOD-like receptor signaling pathway;>>RIG-I-like receptor signaling pathway;>>Cytosolic DNA-sensing pathway;>>JAK-STAT signaling pathway;>>Natural killer cell mediated cytotoxicity;>>Alcoholic liver disease;>>Tuberculosis;>>Hepatitis C;>>Hepatitis B;>>Measles;>>Human cytomegalovirus infection;>>Influenza A;>>Human papillomavirus infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Herpes simplex virus 1 infection;>>Epstein-Barr virus infection;>>Human immunodeficiency virus 1 infection;>>Coronavirus disease - COVID-19;>>Pathways in cancer;>>Autoimmune thyroid disease;>>Lipid and atherosclerosis
Human protein sequence Database
P01563
Mouse protein sequence database
P01573
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Bone marrow tumor,PCR rescued clones,Placenta,Pooled tissue,
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