Molecular weight (DA)
18kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CIRBP Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:Seems to play an essential role in cold-induced suppression of cell proliferation.,induction:By cold stress an in response to DNA damage induced by UV irradiation or UV mimetic agents.,similarity:Contains 1 RRM (RNA recognition motif) domain.,tissue specificity:Ubiquitous.,
Function
function:Seems to play an essential role in cold-induced suppression of cell proliferation.,induction:By cold stress an in response to DNA damage induced by UV irradiation or UV mimetic agents.,similarity:Contains 1 RRM (RNA recognition motif) domain.,tissue specificity:Ubiquitous.,
Gene Name
CIRBP A18HNRNP CIRP
Protein name
Cold-inducible RNA-binding protein (A18 hnRNP) (Glycine-rich RNA-binding protein CIRP)
Human protein sequence Database
Q14011
Mouse protein sequence database
P60824
Rat protein sequence database
P60825
Cellular localization
Nucleus, nucleoplasm . Cytoplasm . Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity). .
Tissue expression
Ubiquitous.
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