Molecular weight (DA)
80kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ES8L1. AA range:411-460
Specificity
Eps8L1 Polyclonal Antibody detects endogenous levels of Eps8L1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. At least two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
function:Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.,similarity:Belongs to the EPS8 family.,similarity:Contains 1 SH3 domain.,subunit:Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin.,tissue specificity:Detected in placenta.,
Protein name
Epidermal growth factor receptor kinase substrate 8-like protein 1
Other name
EPS8L1; DRC3; EPS8R1; PP10566; Epidermal growth factor receptor kinase substrate 8-like protein 1; EPS8-like protein 1; Epidermal growth factor receptor pathway substrate 8-related protein 1; EPS8-related protein 1
Human protein sequence Database
Q8TE68
Mouse protein sequence database
Q8R5F8
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Detected in placenta.
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