Molecular weight (DA)
37kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
APOH Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008],
Function
function:Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.,miscellaneous:In addition to the conflicts shown in the feature table, PubMed:6587378 reports an N-glycosylation site at Asn-188.,online information:The Singapore human mutation and polymorphism database,similarity:Contains 4 Sushi (CCP/SCR) domains.,tissue specificity:Expressed by the liver and secreted in plasma.,
Protein name
Beta-2-glycoprotein 1 (APC inhibitor) (Activated protein C-binding protein) (Anticardiolipin cofactor) (Apolipoprotein H) (Apo-H) (Beta-2-glycoprotein I) (B2GPI) (Beta(2)GPI)
Fields
>>Cholesterol metabolism
Human protein sequence Database
P02749
Mouse protein sequence database
Q01339
Rat protein sequence database
P26644
Cellular localization
Secreted.
Tissue expression
Expressed by the liver and secreted in plasma.
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