Molecular weight (DA)
116kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
PSD4 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:Guanine nucleotide exchange factor for ARF6-like protein. Involved in membrane recycling.,similarity:Contains 1 PH domain.,similarity:Contains 1 SEC7 domain.,subcellular location:Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures.,tissue specificity:Widely expressed. Highest levels of expression are found in placenta, pancreas, spleen, thymus and peripheral blood.,
Function
function:Guanine nucleotide exchange factor for ARF6-like protein. Involved in membrane recycling.,similarity:Contains 1 PH domain.,similarity:Contains 1 SEC7 domain.,subcellular location:Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures.,tissue specificity:Widely expressed. Highest levels of expression are found in placenta, pancreas, spleen, thymus and peripheral blood.,
Protein name
PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein
Human protein sequence Database
Q8NDX1
Mouse protein sequence database
Q8BLR5
Rat protein sequence database
Cellular localization
Cell membrane . Cell projection, ruffle membrane . In interphase associated with the plasma membrane, in particular with membrane ruffling regions (PubMed:23603394). Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures (PubMed:12082148). Recruited to membranes via phosphatidylinositol phosphate-binding (Probable). .
Tissue expression
Widely expressed. Highest levels of expression are found in placenta, pancreas, spleen, thymus and peripheral blood.
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