Molecular weight (DA)
76kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
LAP2A Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Thymopoietin encoded by TMPO resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Function
regulation of transcription,
Protein name
Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thy
Human protein sequence Database
P42166
Mouse protein sequence database
Q61033
Rat protein sequence database
Cellular localization
Nucleus. Chromosome. Expressed diffusely throughout the nucleus.
Tissue expression
Expressed in many tissues. Most abundant in adult thymus and fetal liver.
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