Molecular weight (DA)
34kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 41-90
Specificity
FCN2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
ficolin 2(FCN2) Homo sapiens The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
Function
domain:The fibrinogen-like domain (FBG) contains potential calcium-binding sites that may be involved in carbohydrate binding.,function:May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.,similarity:Belongs to the ficolin lectin family.,similarity:Contains 1 collagen-like domain.,similarity:Contains 1 fibrinogen C-terminal domain.,subunit:Homopolymer; disulfide-linked. Interacts with elastin. Interacts with MASP1 and MASP2.,tissue specificity:Expressed by the liver and secreted in plasma.,
Protein name
Ficolin-2 (37 kDa elastin-binding protein) (Collagen/fibrinogen domain-containing protein 2) (EBP-37) (Ficolin-B) (Ficolin-beta) (Hucolin) (L-ficolin) (Serum lectin p35)
Human protein sequence Database
Q15485
Mouse protein sequence database
O70497
Rat protein sequence database
P57756
Cellular localization
Secreted.
Tissue expression
Expressed by the liver and secreted in plasma.
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