Molecular weight (DA)
52kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
HTRA1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008],
Function
disease:Variations in the promoter region of HTRA1 are the cause of susceptibility to age-related macular degeneration type 7 (ARMD7) [MIM:610149]. ARMD is the leading cause of vision loss and blindness among older individuals in the developed word. It is classified as either dry (nonneovascular) or wet (neovascular). ARMD7 is a wet form, in which new blood vessels form and break beneath the retina. This leakage causes permanent damage to surrounding retinal tissue, distorting and destroying central vision. Wet ARMD is more prevalent among Asians than Caucasians.,function:Protease that regulate the availability of IGFs by cleaving IGF-binding proteins.,similarity:Belongs to the peptidase S1B family.,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 Kazal-like domain.,similarity:Contains 1 PDZ (DHR) domain.,tissue specificity:Expressed in a variety of tissues, with stro
Gene Name
HTRA1 HTRA PRSS11
Protein name
Serine protease HTRA1 (EC 3.4.21.-) (High-temperature requirement A serine peptidase 1) (L56) (Serine protease 11)
Human protein sequence Database
Q92743
Mouse protein sequence database
Q9R118
Rat protein sequence database
Q9QZK5
Cellular localization
Cell membrane . Secreted . Cytoplasm, cytosol . Predominantly secreted (PubMed:15208355). Also found associated with the plasma membrane (PubMed:21297635). .
Tissue expression
Widely expressed, with strongest expression in placenta (at protein level). Secreted by synovial fibroblasts. Up-regulated in osteoarthritis and rheumatoid arthritis synovial fluids and cartilage as compared with non-arthritic (at protein level).
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