Molecular weight (DA)
61kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
GPC1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008],
Function
function:Cell surface proteoglycan that bears heparan sulfate.,PTM:This cell-associated glypican is further processed to give rise to a medium-released species.,similarity:Belongs to the glypican family.,
Protein name
Glypican-1 [Cleaved into: Secreted glypican-1]
Fields
>>Proteoglycans in cancer;>>Fluid shear stress and atherosclerosis
Human protein sequence Database
P35052
Mouse protein sequence database
Q9QZF2
Rat protein sequence database
P35053
Cellular localization
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Endosome. S-nitrosylated form recycled in endosomes. Localizes to CAV1-containing vesicles close to the cell surface. Cleavage of heparan sulfate side chains takes place mainly in late endosomes. Associates with both forms of PRNP in lipid rafts. Colocalizes with APP in perinuclear compartments and with CP in intracellular compartments. Associates with fibrillar APP amyloid-beta peptides in lipid rafts in Alzheimer disease brains.; [Secreted glypican-1]: Secreted, extracellular space.
Tissue expression
Brain,Colon,Lung fibroblast,Salivary gland,
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