Molecular weight (DA)
26kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
RSPO2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the R-spondin family of proteins. These proteins are secreted ligands of leucine-rich repeat containing G protein-coupled receptors that enhance Wnt signaling through the inhibition of ubiquitin E3 ligases. A chromosomal translocation including this locus that results in the formation of a gene fusion has been identified in multiple human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
Function
domain:The FU repeat is required for activation and stabilization of beta-catenin.,function:Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Probably also acts as a ligand for frizzled and LRP receptors.,miscellaneous:Upon injection into mice, it induces rapid onset of crypt cell proliferation involving beta-catenin stabilization. It also displays efficacy in a model of chemotherapy-induced intestinal mucositis.,similarity:Belongs to the R-spondin family.,similarity:Contains 1 FU (furin-like) repeat.,similarity:Contains 1 TSP type-1 domain.,subunit:Interacts with WNT1. Binds heparin.,
Gene Name
RSPO2 UNQ9384/PRO34209
Protein name
R-spondin-2 (Roof plate-specific spondin-2) (hRspo2)
Fields
>>Wnt signaling pathway
Human protein sequence Database
Q6UXX9
Mouse protein sequence database
Q8BFU0
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Lung,Testis,
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