Molecular weight (DA)
29kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
OLIG1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube.,induction:By SHH.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,tissue specificity:Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable.,
Function
function:Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube.,induction:By SHH.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,tissue specificity:Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable.,
Gene Name
OLIG1 BHLHB6 BHLHE21
Protein name
Oligodendrocyte transcription factor 1 (Oligo1) (Class B basic helix-loop-helix protein 6) (bHLHb6) (Class E basic helix-loop-helix protein 21) (bHLHe21)
Human protein sequence Database
Q8TAK6
Mouse protein sequence database
Q9JKN5
Rat protein sequence database
Q9WUQ3
Cellular localization
Nucleus .
Tissue expression
Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable.
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