Molecular weight (DA)
14kD
Immunogen
The antiserum was produced against synthesized peptide derived from human p15 INK. AA range:89-138
Specificity
p15 Polyclonal Antibody detects endogenous levels of p15 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008],
Function
disease:Defects in CDKN2B are involved in tumor formation.,function:Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.,polymorphism:Genetic variations in CDKN2B may underlie susceptibility to uveal melanoma [MIM:155720]. Uveal melanoma is the most common type of ocular malignant tumor, consisting of overgrowth of uveal melanocytes and often preceded by a uveal nevus.,similarity:Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.,similarity:Contains 4 ANK repeats.,subunit:Heterodimer of CDKN2B with CDK4 or CDK6.,
Protein name
Cyclin-dependent kinase 4 inhibitor B
Other name
CDKN2B; MTS2; Cyclin-dependent kinase 4 inhibitor B; Multiple tumor suppressor 2; MTS-2; p14-INK4b; p15-INK4b; p15INK4B
Fields
>>FoxO signaling pathway;>>Cell cycle;>>Cellular senescence;>>TGF-beta signaling pathway;>>Cushing syndrome;>>Human T-cell leukemia virus 1 infection;>>Pathways in cancer;>>Viral carcinogenesis;>>Small cell lung cancer;>>Gastric cancer
Human protein sequence Database
P42772
Mouse protein sequence database
P55271
Rat protein sequence database
P55272
Cellular localization
Cytoplasm . Also found in the nucleus.
Tissue expression
Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines.
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