Molecular weight (DA)
40kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 121-170
Specificity
LFTY1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Aug 2016],
Function
function:Required for left-right axis determination as a regulator of LEFTY2 and NODAL.,PTM:The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.,similarity:Belongs to the TGF-beta family.,
Gene Name
LEFTY1 LEFTB LEFTYB UNQ278/PRO317
Protein name
Left-right determination factor 1 (Left-right determination factor B) (Protein lefty-1) (Protein lefty-B)
Fields
>>TGF-beta signaling pathway;>>Signaling pathways regulating pluripotency of stem cells
Human protein sequence Database
O75610
Mouse protein sequence database
Q64280
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Colon,Pancreas,Spleen,Teratocarcinoma,
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