Molecular weight (DA)
23kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CLC4D Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008],
Function
function:Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells.,induction:Induced by autocrine inflammatory stimuli.,online information:MCL,similarity:Contains 1 C-type lectin domain.,tissue specificity:Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma.,
Gene Name
CLEC4D CLECSF8 MCL
Protein name
C-type lectin domain family 4 member D (C-type lectin superfamily member 8) (C-type lectin-like receptor 6) (CLEC-6)
Fields
>>C-type lectin receptor signaling pathway
Human protein sequence Database
Q8WXI8
Mouse protein sequence database
Q9Z2H6
Rat protein sequence database
Q69FH1
Cellular localization
Cell membrane ; Single-pass type II membrane protein .
Tissue expression
Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma.
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