Molecular weight (DA)
61kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 440-520
Specificity
CHSTF Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Chondroitin sulfate (CS) is a glycosaminoglycan which is an important structural component of the extracellular matrix and which links to proteins to form proteoglycans. Chondroitin sulfate E (CS-E) is an isomer of chondroitin sulfate in which the C-4 and C-6 hydroxyl groups are sulfated. This gene encodes a type II transmembrane glycoprotein that acts as a sulfotransferase to transfer sulfate to the C-6 hydroxal group of chondroitin sulfate. This gene has also been identified as being co-expressed with RAG1 in B-cells and as potentially acting as a B-cell surface signaling receptor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012],
Function
monosaccharide metabolic process, carbohydrate biosynthetic process, hexose metabolic process, hexose biosynthetic process, cellular carbohydrate biosynthetic process, alcohol biosynthetic process, monosaccharide biosynthetic process,
Gene Name
CHST15 BRAG GALNAC4S6ST KIAA0598
Protein name
Carbohydrate sulfotransferase 15 (EC 2.8.2.33) (B-cell RAG-associated gene protein) (hBRAG) (N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase) (GalNAc4S-6ST)
Fields
>>Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Human protein sequence Database
Q7LFX5
Mouse protein sequence database
Q91XQ5
Rat protein sequence database
Q8CHI9
Cellular localization
Golgi apparatus membrane ; Single-pass type II membrane protein . A small fraction may also be present at the cell surface, where it acts as a B-cell receptor.
Tissue expression
Expressed in B-cell-enriched tissues but not in fetal or adult thymus. Expressed in fetal and adult spleen, lymph node, tonsil, bone marrow and peripheral leukocytes. Not expressed in T-cells. In pro-B, pre-B, and mature B-cell lines, it colocalizes with RAG1.
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