Molecular weight (DA)
17kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 1-80
Specificity
RBTN2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
LIM domain only 2(LMO2) Homo sapiens LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008],
Function
disease:A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.,domain:The second LIM zinc-binding domain interacts with KDM5A.,function:Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.,similarity:Contains 2 LIM zinc-binding domains.,subunit:Interacts via its LIM domains with ELF2 and LBD1. Also interacts with basic helix-loop-helix protein TAL1/SCL and can assemble in a complex with LMO2 and TAL1/SCL (By similarity). Interacts with BEX2 and KDM5A.,
Gene Name
LMO2 RBTN2 RBTNL1 RHOM2 TTG2
Protein name
Rhombotin-2 (Cysteine-rich protein TTG-2) (LIM domain only protein 2) (LMO-2) (T-cell translocation protein 2)
Fields
>>Transcriptional misregulation in cancer
Human protein sequence Database
P25791
Mouse protein sequence database
P25801
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Brain,Colon,Kidney,
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