Molecular weight (DA)
58kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PSAP. AA range:307-356
Specificity
Saposin Polyclonal Antibody detects endogenous levels of Saposin protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016],
Function
alternative products:Additional isoforms seem to exist,disease:Defects in PSAP are the cause of combined saposin deficiency (CSAPD) [MIM:611721]; also known as prosaposin deficiency. CSAPD is due to absence of all saposins, leading to a fatal storage disorder with hepatosplenomegaly and severe neurological involvement.,disease:Defects in PSAP saposin-A region are the cause of atypical Krabbe disease (AKRD) [MIM:611722]. AKRD is a disorder of galactosylceramide metabolism. AKRD features include progressive encephalopathy and abnormal myelination in the cerebral white matter resembling Krabbe disease.,disease:Defects in PSAP saposin-B region are the cause of a variant of metachromatic leukodystrophy (MLD) [MIM:249900].,disease:Defects in PSAP saposin-C region are the cause of atypical Gaucher disease (AGD) [MIM:610539]. Affected individuals have marked glucosylceramide accumulation in the
Protein name
Proactivator polypeptide
Other name
PSAP; GLBA; SAP1; Proactivator polypeptide
Fields
>>Sphingolipid metabolism;>>Lysosome
Human protein sequence Database
P07602
Mouse protein sequence database
Q61207
Rat protein sequence database
Cellular localization
Lysosome .; [Prosaposin]: Secreted . Secreted as a fully glycosylated 70 kDa protein composed of complex glycans. .
Tissue expression
Brain,Eye,Kidney,Liver,Milk,Peripheral Nervous System,Skin,Synovial membrane,Urine,
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