Molecular weight (DA)
46kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 20-100
Specificity
TNR19 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008],
Function
function:Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.,similarity:Contains 3 TNFR-Cys repeats.,subunit:Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1.,tissue specificity:Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.,
Gene Name
TNFRSF19 TAJ TROY UNQ1888/PRO4333
Protein name
Tumor necrosis factor receptor superfamily member 19 (TRADE) (Toxicity and JNK inducer)
Fields
>>Cytokine-cytokine receptor interaction
Human protein sequence Database
Q9NS68
Mouse protein sequence database
Q9JLL3
Rat protein sequence database
Cellular localization
Membrane ; Single-pass type I membrane protein .
Tissue expression
Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.
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