Molecular weight (DA)
52kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 310-390
Specificity
PPM1B Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008],
Function
alternative products:Additional isoforms seem to exist,catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 2 magnesium or manganese ions per subunit.,function:Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro.,similarity:Belongs to the PP2C family.,subunit:Monomer.,tissue specificity:Highly expressed in heart and skeletal muscle.,
Protein name
Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta)
Fields
>>MAPK signaling pathway
Human protein sequence Database
O75688
Mouse protein sequence database
P36993
Rat protein sequence database
P35815
Cellular localization
Cytoplasm, cytosol . Membrane ; Lipid-anchor . Weakly associates at the membrane and N-myristoylation mediates the membrane localization. .
Tissue expression
Highly expressed in heart and skeletal muscle.
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