Molecular weight (DA)
50kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 80-160
Specificity
NUD12 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003 [PubMed 12790796]).[supplied by OMIM, Mar 2008],
Function
catalytic activity:NAD(+) + H(2)O = AMP + NMN.,cofactor:Magnesium or manganese.,function:Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle.,similarity:Belongs to the Nudix hydrolase family. NudC subfamily.,similarity:Contains 3 ANK repeats.,
Protein name
Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12)
Fields
>>Nicotinate and nicotinamide metabolism;>>Metabolic pathways;>>Peroxisome
Human protein sequence Database
Q9BQG2
Mouse protein sequence database
Q9DCN1
Rat protein sequence database
Cellular localization
Cytoplasm . Peroxisome . Cytoplasmic granule . Localizes to cytoplasmic granules in the presence of BLMH. .
Tissue expression
Amygdala,Eye,Ovary,
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