Molecular weight (DA)
35kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 70-150
Specificity
CRHBP Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008],
Function
function:Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.,
Protein name
Corticotropin-releasing factor-binding protein (CRF-BP) (CRF-binding protein) (Corticotropin-releasing hormone-binding protein) (CRH-BP)
Human protein sequence Database
P24387
Mouse protein sequence database
Q60571
Rat protein sequence database
P24388
Cellular localization
Secreted.
Tissue expression
Hippocampus,Kidney,Liver,
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