Molecular weight (DA)
46kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 340-420
Specificity
FCRLB Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
FCRL2 belongs to the Fc receptor family. Fc receptors are involved in phagocytosis, antibody-dependent cell cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind immunoglobulin (Ig) constant regions (Chikaev et al., 2005 [PubMed 15676285]).[supplied by OMIM, Mar 2008],
Function
alternative products:Additional isoforms seem to exist,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Seems not to be secreted.,tissue specificity:Expressed at low levels. Expressed in B-lymphocytes. Detected in tonsil, lung, kidney, spleen and placenta. Expressed by a small subset of germinal center B cells in tonsils and by melanocytes (at protein level).,
Gene Name
FCRLB FCRL2 FCRLM2 FCRY FREB2
Protein name
Fc receptor-like B (Fc receptor homolog expressed in B-cells protein 2) (FREB-2) (Fc receptor-like and mucin-like protein 2) (Fc receptor-like protein 2) (Fc receptor-related protein Y) (FcRY)
Human protein sequence Database
Q6BAA4
Mouse protein sequence database
Q5DRQ8
Rat protein sequence database
Cellular localization
Cytoplasm . Endoplasmic reticulum . Seems not to be secreted. .
Tissue expression
Expressed at low levels. Expressed in B-lymphocytes. Detected in tonsil, lung, kidney, spleen and placenta. Expressed by a small subset of germinal center B-cells in tonsils and by melanocytes (at protein level).
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