Molecular weight (DA)
204kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 1551-1600
Specificity
CORA1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the fibrillar collagen family, and plays a role during the calcification of cartilage and the transition of cartilage to bone. The encoded protein product is a preproprotein. It includes an N-terminal signal peptide, which is followed by an N-terminal propetide, mature peptide and a C-terminal propeptide. The N-terminal propeptide contains thrombospondin N-terminal-like and laminin G-like domains. The mature peptide is a major triple-helical region. The C-terminal propeptide, also known as COLFI domain, plays crucial roles in tissue growth and repair. Mutations in this gene cause Steel syndrome. Alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Sep 2014],
Function
developmental stage:Detected at E67 in the primary ossification center and is tightly restricted to the pericellular region of the hypertrophic chondrocytes and lacunae at the very center of the future diaphysis. At fetal 20-week highly abundant in the hypertrophic zone at the chondroosseous junction. Weakly detected around cells in the resting and proliferative zone of the cartilaginous plate, but the intense detection occurred deep in the hypertrophic zone near the newly formed bone. Detected throughout the extracellular matrix (ECM) in this zone it is also closely situated around hypertrophic chondrocytes.,function:Plays a role during the calcification of cartilage and the transition of cartilage to bone.,similarity:Belongs to the fibrillar collagen family.,similarity:Contains 1 laminin G-like domain.,similarity:Contains 1 TSP N-terminal (TSPN) domain.,similarity:Contains 16 collagen-
Gene Name
COL27A1 KIAA1870
Protein name
Collagen alpha-1(XXVII) chain
Fields
>>Protein digestion and absorption
Human protein sequence Database
Q8IZC6
Mouse protein sequence database
Q5QNQ9
Rat protein sequence database
Q80ZF0
Cellular localization
Secreted, extracellular space, extracellular matrix. Found on some small banded collagen fibrils and meshworks. .
Tissue expression
Brain,Cartilage,Epithelium,Skin,Whole embryo,
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