Molecular weight (DA)
47kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 21-70
Specificity
ZBP1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],
Function
alternative products:Additional isoforms seem to exist,function:May play a role in host defense against tumors and pathogens. Binds Z-DNA.,similarity:Contains 2 DRADA repeats.,tissue specificity:Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. Expressed to a lesser extent in thymus, lung and liver.,
Gene Name
ZBP1 C20orf183 DLM1
Protein name
Z-DNA-binding protein 1 (Tumor stroma and activated macrophage protein DLM-1)
Fields
>>Necroptosis;>>Cytosolic DNA-sensing pathway
Human protein sequence Database
Q9H171
Mouse protein sequence database
Q9QY24
Rat protein sequence database
Q8VDA5
Cellular localization
Cytoplasm . Nucleus . Mainly cytoplasmic (PubMed:16876127, PubMed:16990255). Accumulates in the nucleus in response to influenza A virus (IAV) infection: senses IAV defective viral genomes RNA in the nucleus (By similarity). .; [Isoform 7]: Cytoplasm . Nucleus . Compared to isoform 1, a higher proportion of this isoform is localized in the nucleus. .
Tissue expression
Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen (PubMed:11842111). Expressed to a lesser extent in thymus, lung and liver (PubMed:11842111).
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