Molecular weight (DA)
72kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 431-480
Specificity
ANO10 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The transmembrane protein encoded by this gene is a member of a family of calcium-activated chloride channels. Defects in this gene may be a cause of autosomal recessive spinocerebellar ataxia-10. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011],
Function
function:May act as a calcium-activated chloride channel.,sequence caution:Contaminating sequence.,similarity:Belongs to the anoctamin family.,
Protein name
Anoctamin-10 (Transmembrane protein 16K)
Human protein sequence Database
Q9NW15
Mouse protein sequence database
Q8BH79
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein . Shows predominantly an intracellular localization with a weak expression in the cell membrane.
Tissue expression
Highly expressed in the brain. Intermediate levels in the retina and heart and low levels in the placenta, liver, lung, duodenum, kidney, testis and spleen. In brain areas, highest expression in the frontal and occipital cortices and in the cerebellum. Lower expression in the fetal brain than in the adult brain.
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