Molecular weight (DA)
36kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 111-160
Specificity
NIPA1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a magnesium transporter that associates with early endosomes and the cell surface in a variety of neuronal and epithelial cells. This protein may play a role in nervous system development and maintenance. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with autosomal dominant spastic paraplegia 6. [provided by RefSeq, Nov 2008],
Function
disease:Defects in NIPA1 are the cause of spastic paraplegia autosomal dominant type 6 (SPG6) [MIM:600363]. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.,sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,similarity:Belongs to the NIPA family.,tissue specificity:Widely expressed with highest levels in neuronal tissues.,
Protein name
Magnesium transporter NIPA1 (Non-imprinted in Prader-Willi/Angelman syndrome region protein 1) (Spastic paraplegia 6 protein)
Human protein sequence Database
Q7RTP0
Mouse protein sequence database
Q8BHK1
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein . Early endosome . Recruited to the cell membrane in response to low extracellular magnesium. .
Tissue expression
Widely expressed with highest levels in neuronal tissues.
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