Molecular weight (DA)
39kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 30-110
Specificity
AGTR2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation. [provided by RefSeq, Jan 2010],
Function
function:Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with MTUS1.,tissue specificity:In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Very highly expressed in fetal kidney and intestine.,
Protein name
Type-2 angiotensin II receptor (Angiotensin II type-2 receptor) (AT2)
Fields
>>Neuroactive ligand-receptor interaction;>>Adrenergic signaling in cardiomyocytes;>>Renin-angiotensin system
Human protein sequence Database
P50052
Mouse protein sequence database
P35374
Rat protein sequence database
P35351
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine.
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