Molecular weight (DA)
58kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 180-260
Specificity
GP161 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Upon ligand binding, G protein-coupled receptors, such as GPR161, activate cytoplasmic G proteins (see GNAS, MIM 139320), allowing the receptors to transduce extracellular signals across the plasma membrane into the cell. Phosphorylation of the receptor attenuates signaling (Matteson et al., 2008 [PubMed 18250320]).[supplied by OMIM, Aug 2008],
Function
function:Orphan receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
G-protein coupled receptor 161 (G-protein coupled receptor RE2)
Fields
>>Hedgehog signaling pathway
Human protein sequence Database
Q8N6U8
Mouse protein sequence database
B2RPY5
Rat protein sequence database
Cellular localization
Cell projection, cilium membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity). .
Tissue expression
Brain,Fetal brain,Teratocarcinoma,Tongue,
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