Molecular weight (DA)
39kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 290-370
Specificity
GPR78 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an orphan receptor, which displays significant level of constitutive activity. Association analysis shows preliminary evidence for the involvement of this gene in susceptibility to bipolar affective disorder and schizophrenia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011],
Function
function:Orphan receptor.,induction:Expression increased in fibroblasts or HeLa cells following UV-A irradiation, exposure to DNA-alkylating agents, or endoplasmic reticulum (ER) stress caused by osmotic shock or the glycosylation inhibitor tunicamycin.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in pituitary and placenta. No expression detected in brain, skeletal muscle, lung, heart, liver, pancreas, or kidney.,
Gene Name
GPR78 UNQ5925/PRO19818
Protein name
G-protein coupled receptor 78
Human protein sequence Database
Q96P69
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
High level of expression in placenta. Expressed throughout the brain at low level. No expression detected in skeletal muscle, lung, heart, liver, pancreas, or kidney.
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