Molecular weight (DA)
50kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
S29A2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The uptake of nucleosides by transporters, such as SLC29A2, is essential for nucleotide synthesis by salvage pathways in cells that lack de novo biosynthetic pathways. Nucleoside transport also plays a key role in the regulation of many physiologic processes through its effect on adenosine concentration at the cell surface (Griffiths et al., 1997 [PubMed 9396714]).[supplied by OMIM, Nov 2008],
Function
function:Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.,induction:By platelet derived growth factor (PDGF) and fibroblast growth factor (FGF).,similarity:Belongs to the SLC29A transporter family.,tissue specificity:Expressed in placenta, brain, heart and ovarian tissues.,
Gene Name
SLC29A2 DER12 ENT2 HNP36
Protein name
Equilibrative nucleoside transporter 2 (36 kDa nucleolar protein HNP36) (Delayed-early response protein 12) (Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter) (Equil
Human protein sequence Database
Q14542
Mouse protein sequence database
Q61672
Rat protein sequence database
O54699
Cellular localization
Basolateral cell membrane ; Multi-pass membrane protein . Nucleus membrane ; Multi-pass membrane protein . Localized at the basolateral cell membrane in polarized MDCK cells.
Tissue expression
Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues.
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