Molecular weight (DA)
37kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 230-310
Specificity
TA2R Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
thromboxane A2 receptor(TBXA2R) Homo sapiens This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009],
Function
disease:Defects in TBXA2R are the cause of a dominantly inherited bleeding disorder [MIM:188070].,function:Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase, isoform 2 inhibits adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor)
Fields
>>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Platelet activation
Human protein sequence Database
P21731
Mouse protein sequence database
P30987
Rat protein sequence database
P34978
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Blood,Endothelial cell,Lung,PCR rescued clones,Placenta,Platelet,
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