Molecular weight (DA)
71kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 268-318
Specificity
TRXR1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
thioredoxin reductase 1(TXNRD1) Homo sapiens This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.,cofactor:Binds 1 FAD per subunit.,domain:The N-terminal glutaredoxin domain found in isoform 1 does not contain the C-P-Y-C redox-active motif normally found in glutaredoxins and has been found to be inactive in classical glutaredoxin assays.,function:Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.,induction:Isoform 5 is induced by a combination of interferon-beta and retinoic acid (at protein level). Isoform 1 is induced b
Gene Name
TXNRD1 GRIM12 KDRF
Protein name
Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12
Fields
>>Selenocompound metabolism;>>Pathways in cancer;>>Hepatocellular carcinoma
Human protein sequence Database
Q16881
Mouse protein sequence database
Q9JMH6
Rat protein sequence database
O89049
Cellular localization
[Isoform 1]: Cytoplasm .; [Isoform 4]: Cytoplasm . Nucleus .; [Isoform 5]: Cytoplasm .
Tissue expression
[Isoform 1]: Expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. ; [Isoform 4]: Widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver.
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