Molecular weight (DA)
121kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
ESYT1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:May play a role as calcium-regulated intrinsic membrane protein.,similarity:Belongs to the extended synaptotagmin family.,similarity:Contains 5 C2 domains.,subcellular location:Localizes to intracellular membranes.,tissue specificity:Widely expressed.,
Function
function:May play a role as calcium-regulated intrinsic membrane protein.,similarity:Belongs to the extended synaptotagmin family.,similarity:Contains 5 C2 domains.,subcellular location:Localizes to intracellular membranes.,tissue specificity:Widely expressed.,
Gene Name
ESYT1 FAM62A KIAA0747 MBC2
Protein name
Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein)
Human protein sequence Database
Q9BSJ8
Mouse protein sequence database
Q3U7R1
Rat protein sequence database
Q9Z1X1
Cellular localization
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell membrane ; Peripheral membrane protein . Localizes primarily to the endoplasmic reticulum (PubMed:29469807). Recruited to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:29469807, PubMed:22250200). .
Tissue expression
Widely expressed.
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