Molecular weight (DA)
26kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
TNR18 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011],
Function
function:Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.,induction:Up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.,similarity:Contains 3 TNFR-Cys repeats.,subunit:Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6. Binds through its C-terminus to SIVA1/SIVA.,tissue specificity:Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.,
Gene Name
TNFRSF18 AITR GITR UNQ319/PRO364
Protein name
Tumor necrosis factor receptor superfamily member 18 (Activation-inducible TNFR family receptor) (Glucocorticoid-induced TNFR-related protein) (CD antigen CD357)
Fields
>>Cytokine-cytokine receptor interaction
Human protein sequence Database
Q9Y5U5
Mouse protein sequence database
O35714
Rat protein sequence database
Cellular localization
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
Tissue expression
Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.
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