Molecular weight (DA)
51kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
MYCN Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog(MYCN) Homo sapiens This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014],
Function
developmental stage:Expressed during fetal development.,disease:Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses.,disease:Defects in MYCN are the cause of Feingold syndrome [MIM:164280]; also known as oculodigitoesophagoduodenal syndrome (ODED). Feingold syndrome is characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability and limb malformations. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described.,disease:Defects in MYCN are the cause of microcephaly and digital abnormalities with normal intelligence [MIM:602585].,function:May function as a transcription factor.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires di
Gene Name
MYCN BHLHE37 NMYC
Protein name
N-myc proto-oncogene protein (Class E basic helix-loop-helix protein 37) (bHLHe37)
Fields
>>Transcriptional misregulation in cancer
Human protein sequence Database
P04198
Mouse protein sequence database
P03966
Rat protein sequence database
Q63379
Cellular localization
Nucleus.
Tissue expression
Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level).
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