Molecular weight (DA)
67kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ME3. AA range:545-594
Specificity
ME3 Polyclonal Antibody detects endogenous levels of ME3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008],
Function
catalytic activity:(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH.,cofactor:Divalent metal cations. Prefers magnesium or manganese.,similarity:Belongs to the malic enzymes family.,tissue specificity:Expressed predominantly in organs with a low-division rate.,
Protein name
NADP-dependent malic enzyme mitochondrial
Other name
ME3; NADP-dependent malic enzyme; mitochondrial; NADP-ME; Malic enzyme 3
Fields
>>Pyruvate metabolism;>>Metabolic pathways;>>Carbon metabolism;>>PPAR signaling pathway
Human protein sequence Database
Q16798
Mouse protein sequence database
Q8BMF3
Rat protein sequence database
Cellular localization
Mitochondrion matrix.
Tissue expression
Expressed predominantly in organs with a low-division rate.
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