Molecular weight (DA)
28kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
RFA4 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.[provided by RefSeq, Apr 2010],
Function
function:Absolutely required for simian virus 40 DNA replication in vitro. It participates in a very early step in initiation. RP-A is a single-stranded DNA-binding protein.,subunit:Interacts with RPA1 and RPA3. In a tissue-specic manner, may replace RPA2 in the replication protein A heterotrimer.,tissue specificity:Preferentially expressed in placental and colon mucosa.,
Protein name
Replication protein A 30 kDa subunit (RP-A p30) (Replication factor A protein 4) (RF-A protein 4)
Fields
>>DNA replication;>>Nucleotide excision repair;>>Mismatch repair;>>Homologous recombination;>>Fanconi anemia pathway
Human protein sequence Database
Q13156
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus . Localizes to DNA repair foci after DNA damage.
Tissue expression
Preferentially expressed in placental and colon mucosa. Widely expressed at intermediate or lower levels.
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