Molecular weight (DA)
65kD
Immunogen
The antiserum was produced against synthesized peptide derived from human IL-1Ralpha/CD121alpha around the phosphorylation site of Tyr496. AA range:471-520
Specificity
Phospho-IL-1RI (Y496) Polyclonal Antibody detects endogenous levels of IL-1RI protein only when phosphorylated at Y496.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013],
Function
function:Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2.,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds IL1RAP.,
Protein name
Interleukin-1 receptor type 1
Other name
IL1R1; IL1R; IL1RA; IL1RT1; Interleukin-1 receptor type 1; IL-1R-1; IL-1RT-1; IL-1RT1; CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha; Interleukin-1 receptor type I; p80; CD antigen CD121a
Fields
>>MAPK signaling pathway;>>Cytokine-cytokine receptor interaction;>>NF-kappa B signaling pathway;>>Osteoclast differentiation;>>Hematopoietic cell lineage;>>Th17 cell differentiation;>>Inflammatory mediator regulation of TRP channels;>>Pathogenic Escherichia coli infection;>>Shigellosis;>>Amoebiasis;>>Human cytomegalovirus infection;>>Human T-cell leukemia virus 1 infection;>>Fluid shear stress and atherosclerosis
Human protein sequence Database
P14778
Mouse protein sequence database
P13504
Rat protein sequence database
Q02955
Cellular localization
Membrane ; Single-pass type I membrane protein . Cell membrane . Secreted .
Tissue expression
Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells.
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