Molecular weight (DA)
20kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
COPT1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded protein functions as a homotrimer to effect the uptake of dietary copper. [provided by RefSeq, Aug 2011],
Function
function:Involved in high-affinity copper uptake.,PTM:O-Glycosylation at Thr-27 protects from proteolytic cleavage in the N-terminal extracellular domain.,similarity:Belongs to the SLC31A transporter family.,subunit:Homotrimer.,
Gene Name
SLC31A1 COPT1 CTR1
Protein name
High affinity copper uptake protein 1 (Copper transporter 1) (hCTR1) (Solute carrier family 31 member 1)
Fields
>>Platinum drug resistance;>>Mineral absorption
Human protein sequence Database
O15431
Mouse protein sequence database
Q8K211
Rat protein sequence database
Q9JK41
Cellular localization
Cell membrane; Multi-pass membrane protein. Localizes to the apical membrane in intestinal epithelial cells. .
Tissue expression
Brain,Liver,Lung,Skeletal muscle,Skin,
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