Molecular weight (DA)
20kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
GGCT Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],
Function
catalytic activity:(Gamma-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.,function:Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.,induction:By geranylgeraniol.,similarity:Belongs to the gamma-glutamylcyclotransferase family.,subunit:Homodimer.,
Gene Name
GGCT C7orf24 CRF21
Protein name
Gamma-glutamylcyclotransferase (EC 2.3.2.4) (Cytochrome c-releasing factor 21)
Fields
>>Glutathione metabolism;>>Metabolic pathways
Human protein sequence Database
O75223
Mouse protein sequence database
Q9D7X8
Rat protein sequence database
Cellular localization
cytosol,extracellular exosome,
Tissue expression
Kidney,Lung,Skeletal muscle,Skin,Urinary bladder,
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车