Molecular weight (DA)
25kD
Immunogen
Synthesized peptide derived from human IFI30 AA range: 3-53
Specificity
This antibody detects endogenous levels of IFI30 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.06% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. [provided by RefSeq, Jul 2008],
Function
function:Cleaves disulfide bonds in proteins by reduction. May facilitate the complete unfolding of proteins destined for lysosomal degradation. May be involved in MHC class II-restricted antigen processing.,induction:Expressed constitutively in antigen-presenting cells and induced by IFN-gamma in other cell types.,PTM:N-glycosylated. Sugar chains contain mannose-6-phosphate.,similarity:Belongs to the GILT family.,
Gene Name
IFI30 GILT IP30
Other name
Gamma-interferon-inducible lysosomal thiol reductase (EC 1.8.-.-) (Gamma-interferon-inducible protein IP-30) (Legumaturain)
Fields
>>Antigen processing and presentation
Human protein sequence Database
P13284
Mouse protein sequence database
Q9ESY9
Rat protein sequence database
Q499T2
Cellular localization
Secreted . Lysosome .
Tissue expression
Lung,Skin,
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