Molecular weight (DA)
38kD
Immunogen
Synthesized peptide derived from human TMOD2 AA range: 138-188
Specificity
This antibody detects endogenous levels of TMOD2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.13% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008],
Function
function:Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton.,similarity:Belongs to the tropomodulin family.,subunit:Binds to the N-terminus of tropomyosin and to actin.,tissue specificity:Neuronal-tissue specific.,
Other name
Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod)
Human protein sequence Database
Q9NZR1
Mouse protein sequence database
Q9JKK7
Rat protein sequence database
P70566
Cellular localization
Cytoplasm, cytoskeleton .
Tissue expression
Neuronal-tissue specific.
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