Molecular weight (DA)
38kD
Immunogen
Synthesized peptide derived from human PDLI2 AA range: 190-240
Specificity
This antibody detects endogenous levels of PDLI2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.22% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011],
Function
function:Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 1 PDZ (DHR) domain.,subcellular location:Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN).,subcellular location:May be partially nuclear.,subunit:Interacts with alpha-actinins ACTN1 and ACTN4, FLNA and MYH9.,
Other name
PDZ and LIM domain protein 2 (PDZ-LIM protein mystique)
Human protein sequence Database
Q96JY6
Mouse protein sequence database
Q8R1G6
Rat protein sequence database
Q6AYD6
Cellular localization
Cytoplasm . Nucleus . May be partially nuclear.; [Isoform 1]: Cytoplasm, cytoskeleton. Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN).; [Isoform 2]: Cytoplasm, cytoskeleton.; [Isoform 3]: Nucleus.
Tissue expression
Epithelium,Hypothalamus,Placenta,Spleen,
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