Molecular weight (DA)
38kD
Immunogen
Synthesized peptide derived from human OTX1 AA range: 236-286
Specificity
This antibody detects endogenous levels of OTX1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.61% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mouse is required for proper brain and sensory organ development and can cause epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015],
Function
developmental stage:Embryo.,function:Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.,similarity:Belongs to the paired homeobox family. Bicoid subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Expressed in brain.,
Other name
Homeobox protein OTX1 (Orthodenticle homolog 1)
Fields
>>Signaling pathways regulating pluripotency of stem cells
Human protein sequence Database
P32242
Mouse protein sequence database
P80205
Rat protein sequence database
Q63410
Cellular localization
Nucleus .
Tissue expression
Expressed in brain. Detected in the anterior part of the neural fetal retina (at protein level).
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