Immunogen
Synthesized peptide derived from human NBPFC AA range: 119-169
Specificity
This antibody detects endogenous levels of NBPFC at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, mental retardation, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This
Function
miscellaneous:Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.,similarity:Belongs to the NBPF family.,similarity:Contains 10 NBPF domains.,similarity:Contains 2 NBPF domains.,similarity:Contains 3 NBPF domains.,similarity:Contains 6 NBPF domains.,similarity:Contains 7 NBPF domains.,similarity:Contains 8 NBPF domains.,tissue specificity:Expressed in a neuroblastoma cell line.,tissue specificity:Expressed in spinal cord.,tissue specificity:Expressed in spleen and fetal liver.,tissue specificity:Expressed in the mammary gland.,tissue specificity:Ubiquitously expressed with a higher expression observed in breast and liver. Also expressed in neuroblastoma cell line.,tissue specificity:Widely expressed. The only tissue which shows a weak expression is kidney.,
Gene Name
NBPF12 COAS1 KIAA1245
Human protein sequence Database
Q5TAG4
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Widely expressed with highest levels in brain, ovary, mammary gland, skin and adipose tissue. Also expressed in testis. Detected in a number of tumors including osteosarcoma, mammary carcinoma and hepatocellular carcinoma.
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