Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from human EFS AA range: 108-158
Specificity
This antibody detects endogenous levels of EFS at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.86% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The longest protein isoform encoded by this gene contains an SH3 domain, which is known to be important in intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to bind to SH3 domains of protein-tyrosine kinases. The function of this gene is unknown. Three alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2013],
Function
domain:Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains.,domain:The SH3-binding sites that bind to the SRC SH3 domain are required for interaction with CRK and are implicated in promotion of serum response element (SRE) activation. The SH3 domain interacts with focal adhesion kinase 1.,function:Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES.,PTM:Phosphorylated on multiple tyrosine residues. Phosphorylated on tyrosines by FYN and SRC.,similarity:Belongs to the CAS family.,similarity:Contains 1 SH3 domain.,tissue
Other name
Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3)
Human protein sequence Database
O43281
Mouse protein sequence database
Q64355
Rat protein sequence database
Cellular localization
cytoplasm,
Tissue expression
The protein has been detected in lung and placenta.
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