Immunogen
Synthesized peptide derived from human SESN3 AA range: 35-85
Specificity
This antibody detects endogenous levels of SESN3 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012],
Function
caution:Positions 27 to 191 are in EST BF328700; positions 244 to 492 can be found in EST BG291497 but several frameshifts need to be corrected to restore the correct sequence. Positions 412 to 492 are in AF086251 with no conflicts.,similarity:Belongs to the sestrin family.,tissue specificity:Widely expressed.,
Fields
>>p53 signaling pathway;>>Longevity regulating pathway
Human protein sequence Database
P58005
Mouse protein sequence database
Q9CYP7
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Widely expressed.
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